IGKV3OR2-268

Across TCGA pan-cancer cohorts, IGKV3OR2-268 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGKV3OR2-268 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3OR2-268 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3OR2-268 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV3OR2-268 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.751	0.641	<.001	138	view →
SKCM	OS	Median	All	0.421	0.270	<.001	119	view →
BRCA	OS	Quartile	All	0.679	0.529	<.001	59	view →
SARC	OS	Median	All	0.917	0.738	<.001	33	view →
KIRC	DFS	Median	IV	0.237	0.426	.013	27	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
CESC	OS	Tertile	All	0.851	0.702	.007	18	view →
COAD	OS	Median	III,IV	0.893	0.674	.001	17	view →
LIHC	DFS	Quartile	III,IV	0.574	0.250	.022	15	view →
CHOL	DFS	Tertile	All	0.768	0.268	.003	15	view →
KIRP	OS	Quartile	All	0.610	0.822	.004	10	view →
TGCT	DFS	Tertile	All	0.958	0.742	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGKV3OR2-268–HNSC (DFS)

Open the HNSC breakdown →