IGKV3OR2-268

Across TCGA pan-cancer cohorts, IGKV3OR2-268 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGKV3OR2-268’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV3OR2-268 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV3OR2-268 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGKV3OR2-268 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV3OR2-268 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.864	<.001	10	view →
LUAD	Female	All	+1.592	<.001	7	view →
KIRC	Male	All	+0.750	<.001	6	view →
BRCA	Female	II,III,IV	−0.531	.003	4	view →
READ	All	All	−3.073	<.001	3	view →
ESCA	All	All	+1.484	.012	3	view →
STAD	All	IV	−3.836	.007	2	view →
KICH	All	All	−0.576	.023	2	view →
LUSC	All	All	+0.662	.029	1	view →
LIHC	Male	All	−0.500	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGKV3OR2-268–COAD

Open the COAD breakdown →