IGKV3OR2-268

Across TCGA pan-cancer cohorts, IGKV3OR2-268 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV3OR2-268 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher IGKV3OR2-268 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGKV3OR2-268 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC and CCRCC are the cancer types where IGKV3OR2-268 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.982	0.554	.018	8	view →
CCRCC	DFS	Tertile	III,IV	0.784	0.246	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV3OR2-268–LSCC (OS)

Open the LSCC breakdown →