IGKV3D-34

Across TCGA patient cohorts, IGKV3D-34 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,053 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV3D-34-associated GO terms across cancer lineages are B cell mediated immunity, Antimicrobial humoral response, and Humoral immune response mediated by circulating immunoglobulin. Each is linked with IGKV3D-34 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGKV3D-34-to-partner and partner-to-IGKV3D-34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV3D-34-low versus IGKV3D-34-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-34→partner) and Y-score (partner→IGKV3D-34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.120	+0.008	<.001	.006	2	5
STAD	Antimicrobial humoral response →	+0.124	+0.020	<.001	.004	3	4
STAD	Humoral immune response mediated by circulating immunoglobulin →	+0.122	+0.022	<.001	.002	3	4
STAD	Humoral immune response →	+0.092	+0.024	<.001	<.001	3	4
THCA	Immunoglobulin production →	+0.094	+0.013	<.001	.004	3	4
STAD	Regulation of lymphocyte chemotaxis →	+0.088	+0.018	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

B cell mediated immunity by IGKV3D-34 expression — THCA

Explore this box plot interactively →