IGKV3D-34

Across TCGA pan-cancer cohorts, IGKV3D-34 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGKV3D-34 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IGKV3D-34 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3D-34 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

BLCA, GBM, and STAD are the cancer types where IGKV3D-34 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.109	0.724	<.001	108	view →
GBM	OS	Tertile	All	0.026	0.416	<.001	36	view →
STAD	OS	Tertile	IV	0.001	0.544	<.001	36	view →
HNSC	DFS	Tertile	IV	1.000	0.304	.020	24	view →
THYM	DFS	Tertile	All	0.134	0.871	<.001	18	view →
LAML	DFS	Tertile	All	0.028	0.583	.001	18	view →
PRAD	DFS	Tertile	All	0.152	0.774	.014	18	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGKV3D-34–BLCA (OS)

Open the BLCA breakdown →