Across TCGA patient cohorts, IGKV3D-20 protein abundance is significantly associated with the RNA expression of many other genes, with 13,766 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV3D-20-associated genes across cancer lineages are IGHV4-59, CD79A, and LAX1. Each is linked with IGKV3D-20 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGKV3D-20-to-partner and partner-to-IGKV3D-20 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-20→partner) and Y-score (partner→IGKV3D-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGHV4-59 →	+2.279	+0.864	<.001	<.001	3	6
BRCA	CD79A →	+1.238	+0.442	<.001	.008	3	5
BRCA	LAX1 →	+0.978	+0.719	<.001	<.001	3	5
LSCC	TBC1D27P →	+0.374	+0.410	<.001	<.001	3	5
BRCA	IRF4 →	+0.920	+0.605	.001	.002	3	5
LUAD	FCRL5 →	+0.998	+0.623	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,766 associations by consensus.

Exploration

IGKV3D-20 survival (RNA) · tumor vs normal (RNA) · all IGKV3D-20 data types