IGKV3D-11

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGKV3D-11 mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV3D-11-associated genes across cancer lineages are RNA5SP198, RNA5SP518, and RNA5SP480. Each is linked with IGKV3D-11 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGKV3D-11-to-partner and partner-to-IGKV3D-11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-11→partner) and Y-score (partner→IGKV3D-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMRNA5SP198 →+0.218+5.039<.001.00333
LUADRNA5SP518 →+0.090+5.117<.001.00132
LUADRNA5SP480 →+0.117+4.792.001.00232
LUSCRNU7-196P →+0.265+3.040<.001.00832
UCECFOXC2-AS1 →+0.906+4.560<.001.00132
UCECRNU1-115P →+0.241+5.464<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

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