IGKV3D-11

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGKV3D-11 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV3D-11-associated genes across cancer lineages are CD8+ T-cells, MEP, and DC. Each is linked with IGKV3D-11 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3D-11-to-partner and partner-to-IGKV3D-11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3D-11→partner) and Y-score (partner→IGKV3D-11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADCD8+ T-cells →+0.023+1.992.026.04731
LUSCMEP →+0.022+2.381.038.01831
LUSCDC →-0.026-3.435.022.00521
Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

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