IGKV3-7

Across TCGA patient cohorts, IGKV3-7 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,767 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV3-7-associated proteins across cancer lineages are DOCK2, HCLS1, and IL16. Each is linked with IGKV3-7 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGKV3-7-to-partner and partner-to-IGKV3-7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-7 versus DOCK2 in LSCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-7→partner) and Y-score (partner→IGKV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DOCK2 →	+0.517	+1.509	<.001	<.001	3	10
GBM	HCLS1 →	+0.669	+0.161	<.001	.002	3	10
OV	IL16 →	+0.610	+0.569	<.001	<.001	3	10
OV	MZB1 →	+1.227	+0.464	<.001	<.001	3	10
LSCC	CD38 →	+0.892	+1.744	<.001	<.001	3	9
OV	CORO1A →	+0.584	+0.648	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,767 associations by consensus.

IGKV3-7 vs DOCK2 — LSCC

Explore this scatter interactively →