IGKV3-7

Across TCGA pan-cancer cohorts, IGKV3-7 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGKV3-7 data layer compared with 5 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-7 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, UVM, and SKCM are the cancer types where IGKV3-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.780	0.638	<.001	142	view →
UVM	DFS	Tertile	All	0.449	0.811	.001	99	view →
SKCM	OS	Median	All	0.428	0.255	<.001	75	view →
BRCA	OS	Quartile	All	0.981	0.932	<.001	53	view →
COAD	DFS	Median	II,III,IV	0.801	0.573	<.001	47	view →
UCEC	OS	Quartile	III,IV	0.907	0.730	.003	46	view →
PAAD	OS	Median	II,III,IV	0.453	0.303	.002	34	view →
CESC	OS	Median	II,III,IV	0.915	0.723	.002	26	view →
CHOL	DFS	Tertile	All	0.703	0.224	.003	18	view →
TGCT	DFS	Tertile	All	0.962	0.716	<.001	18	view →
BLCA	DFS	Tertile	All	0.740	0.517	.013	18	view →
KIRP	DFS	Quartile	All	0.521	0.834	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGKV3-7–HNSC (DFS)

Open the HNSC breakdown →