IGKV3-7

Across TCGA patient cohorts, IGKV3-7 protein abundance is significantly associated with the RNA expression of many other genes, with 8,710 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV3-7-associated genes across cancer lineages are CR1, CD180, and IGKV3-20. Each is linked with IGKV3-7 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGKV3-7-to-partner and partner-to-IGKV3-7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-7 versus CR1 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-7→partner) and Y-score (partner→IGKV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CR1 →	+1.044	+0.604	<.001	<.001	3	6
LSCC	CD180 →	+0.736	+0.408	<.001	.001	3	5
OV	IGKV3-20 →	+3.265	+0.603	.001	.001	3	5
LUAD	SOCS3 →	+0.847	+0.417	<.001	.001	3	5
LSCC	IGHV3OR16-9 →	+1.298	+0.369	<.001	.001	3	5
GBM	CD93 →	+0.705	+0.398	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,710 associations by consensus.

IGKV3-7 vs CR1 — GBM

Explore this scatter interactively →