IGKV3-7

Across TCGA patient cohorts, IGKV3-7 mutation is significantly associated with the RNA expression of many other genes, with 153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV3-7-associated genes across cancer lineages are TEDDM2P, MIR7702, and RNU7-128P. Each is linked with IGKV3-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3-7-to-partner and partner-to-IGKV3-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEDDM2P grouped by IGKV3-7-low versus IGKV3-7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-7→partner) and Y-score (partner→IGKV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TEDDM2P →	+0.030	+3.300	.009	.007	3	2
UCEC	MIR7702 →	+0.373	+5.060	<.001	.001	3	2
LUSC	RNU7-128P →	+0.604	+3.224	.001	.005	3	2
LUSC	LINC02855 →	+0.139	+3.678	<.001	.004	3	2
BRCA	RNU6-1320P →	+0.282	+8.055	<.001	.007	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 153 associations by consensus.

TEDDM2P by IGKV3-7 expression — SKCM

Explore this box plot interactively →