IGKV3-7

Across TCGA patient cohorts, IGKV3-7 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV3-7-associated genes across cancer lineages are iDC, Astrocytes, and Epithelial cells. Each is linked with IGKV3-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV3-7-to-partner and partner-to-IGKV3-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, iDC grouped by IGKV3-7-low versus IGKV3-7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-7→partner) and Y-score (partner→IGKV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	iDC →	+0.349	+2.816	<.001	.036	3	1
SKCM	Astrocytes →	+0.066	+2.825	<.001	.010	3	1
UCEC	Epithelial cells →	-0.104	-3.161	.008	.019	2	1
SKCM	Endothelial cells →	+0.060	+2.813	.011	.037	1	1
UCEC	Class-switched memory B-cells →	-0.064	-3.169	.040	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

iDC by IGKV3-7 expression — SKCM

Explore this box plot interactively →