IGKV3-31

Across TCGA patient cohorts, IGKV3-31 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,203 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV3-31-associated GO terms across cancer lineages are B cell mediated immunity, Antigen receptor-mediated signaling pathway, and Positive regulation of immune effector process. Each is linked with IGKV3-31 in more than 14 cancer types. Because this analysis shows association rather than direction, both IGKV3-31-to-partner and partner-to-IGKV3-31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV3-31-low versus IGKV3-31-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-31→partner) and Y-score (partner→IGKV3-31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	B cell mediated immunity →	+0.094	+0.028	<.001	<.001	3	15
SARC	Antigen receptor-mediated signaling pathway →	+0.092	+0.025	<.001	.004	2	15
STAD	Positive regulation of immune effector process →	+0.062	+0.098	<.001	<.001	3	14
SARC	Regulation of CD4-positive, alpha-beta T cell activation →	+0.087	+0.021	<.001	.003	3	13
SARC	Positive regulation of alpha-beta T cell activation →	+0.100	+0.024	<.001	.004	2	14
STAD	Regulation of adaptive immune response →	+0.068	+0.090	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,203 associations by consensus.

B cell mediated immunity by IGKV3-31 expression — THCA

Explore this box plot interactively →