IGKV3-31

Across TCGA pan-cancer cohorts, IGKV3-31 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGKV3-31 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGKV3-31 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3-31 expression acts as an unfavorable survival marker, although some lineages such as OV and MESO show a favorable association.

ESCA, SKCM, and LUSC are the cancer types where IGKV3-31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
SKCM	DFS	Tertile	II,III,IV	0.303	0.570	.011	33	view →
LUSC	DFS	Tertile	II,III,IV	0.456	0.777	.017	18	view →
KIRC	DFS	Tertile	IV	0.167	0.605	<.001	18	view →
COAD	DFS	Tertile	All	0.120	0.561	.047	9	view →
THYM	DFS	Tertile	All	0.134	0.871	<.001	9	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
OV	DFS	Tertile	II,III,IV	0.831	0.534	.040	6	view →
HNSC	OS	Tertile	All	0.133	0.415	.038	6	view →
MESO	OS	Tertile	All	0.840	0.365	.030	3	view →
LUAD	OS	Tertile	III,IV	0.889	0.638	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGKV3-31–ESCA (OS)

Open the ESCA breakdown →