IGKV3-25

Across TCGA pan-cancer cohorts, IGKV3-25 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGKV3-25 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-25 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-25 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, OV, and STAD are the cancer types where IGKV3-25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.486	0.294	<.001	105	view →
OV	DFS	Tertile	II,III,IV	0.267	0.543	.013	54	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	39	view →
PAAD	OS	Tertile	II,III,IV	0.866	0.504	.015	21	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
COAD	DFS	Tertile	III,IV	0.442	0.671	.038	9	view →
READ	OS	Tertile	All	0.787	0.948	.017	9	view →
LUSC	OS	Tertile	III,IV	0.699	0.257	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV3-25–HNSC (DFS)

Open the HNSC breakdown →