IGKV3-25

Across TCGA pan-cancer cohorts, IGKV3-25 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGKV3-25’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV3-25 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV3-25 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

LUAD and BRCA are the cancer types where IGKV3-25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV3-25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.166	.001	5	view →
BRCA	Female	All	−0.038	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGKV3-25–LUAD

Open the LUAD breakdown →