IGKV3-20

Across TCGA pan-cancer cohorts, IGKV3-20 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGKV3-20 data layer compared with 23 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-20 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV3-20 expression acts as an unfavorable survival marker.

HNSC, BLCA, and LIHC are the cancer types where IGKV3-20 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.057	0.768	<.001	30	view →
BLCA	OS	Median	III,IV	0.276	0.657	.005	15	view →
LIHC	DFS	Median	All	0.093	0.543	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IGKV3-20–HNSC (OS)

Open the HNSC breakdown →