IGKV3-20

Across TCGA pan-cancer cohorts, IGKV3-20 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated IGKV3-20 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGKV3-20 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV3-20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

COAD, LUAD, and HNSC are the cancer types where IGKV3-20 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.918	1.000	.011	60	view →
LUAD	OS	Median	All	0.890	1.000	.004	18	view →
HNSC	OS	Median	All	1.000	0.449	.023	15	view →
GBM	DFS	Tertile	All	0.523	0.213	.013	9	view →
CCRCC	DFS	Quartile	All	0.830	0.495	.016	4	view →
LSCC	OS	Median	All	0.931	0.822	.021	3	view →
PDAC	OS	Median	II,III,IV	0.571	0.421	.026	2	view →
UCEC	DFS	Median	II,III,IV	0.826	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV3-20–COAD (DFS)

Open the COAD breakdown →