IGKV3-15

Across TCGA patient cohorts, IGKV3-15 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,968 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV3-15-associated proteins across cancer lineages are WIPF1, PTPN7, and DOCK2. Each is linked with IGKV3-15 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGKV3-15-to-partner and partner-to-IGKV3-15 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-15 versus WIPF1 in LSCC, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-15→partner) and Y-score (partner→IGKV3-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WIPF1 →	+0.360	+1.430	<.001	<.001	3	10
HNSC	PTPN7 →	+0.546	+2.510	<.001	<.001	3	10
LSCC	DOCK2 →	+0.617	+1.762	<.001	<.001	3	10
GBM	HCLS1 →	+0.664	+1.722	<.001	<.001	3	10
OV	IL16 →	+0.659	+3.720	<.001	<.001	3	10
BRCA	ISG20 →	+0.813	+2.713	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,968 associations by consensus.

IGKV3-15 vs WIPF1 — LSCC

Explore this scatter interactively →