IGKV3-11

Across TCGA pan-cancer cohorts, IGKV3-11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGKV3-11 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV3-11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-11 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where IGKV3-11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.712	0.174	.011	13	view →
HNSC	DFS	Median	All	1.000	0.441	.039	9	view →
CCRCC	DFS	Median	II,III,IV	0.295	0.827	.010	8	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGKV3-11–LUAD (DFS)

Open the LUAD breakdown →