IGKV2OR22-4

Across TCGA patient cohorts, IGKV2OR22-4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV2OR22-4-associated genes across cancer lineages are RNA5SP376, RNU6-1090P, and TTTY4B. Each is linked with IGKV2OR22-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2OR22-4-to-partner and partner-to-IGKV2OR22-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP376 grouped by IGKV2OR22-4-low versus IGKV2OR22-4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2OR22-4→partner) and Y-score (partner→IGKV2OR22-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP376 →	+0.556	+8.066	<.001	.007	3	1
LUSC	RNU6-1090P →	+0.422	+7.924	<.001	.008	3	1
LUSC	TTTY4B →	+0.019	+7.924	<.001	.008	3	1
LUSC	TSPY21P →	+0.039	+7.924	<.001	.008	3	1
LUSC	RNU7-105P →	+0.566	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RNA5SP376 by IGKV2OR22-4 expression — UCEC

Explore this box plot interactively →