IGKV2OR22-4

Across TCGA pan-cancer cohorts, IGKV2OR22-4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IGKV2OR22-4 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR22-4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2OR22-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, ACC, and SKCM are the cancer types where IGKV2OR22-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.673	0.533	<.001	145	view →
ACC	DFS	Tertile	All	0.140	0.621	<.001	105	view →
SKCM	DFS	Tertile	All	0.688	0.567	.001	72	view →
CESC	OS	Tertile	All	0.890	0.733	.003	44	view →
UCEC	DFS	Median	II,III,IV	0.689	0.269	.015	42	view →
BLCA	DFS	Tertile	All	0.465	0.188	.007	33	view →
LIHC	DFS	Median	III,IV	0.601	0.259	.009	32	view →
BRCA	DFS	Median	All	0.965	0.932	.006	24	view →
KIRP	OS	Quartile	All	0.469	0.769	.004	21	view →
STAD	DFS	Median	All	0.558	0.694	.009	19	view →
CHOL	DFS	Tertile	All	0.714	0.233	.005	18	view →
GBM	OS	Tertile	All	0.262	0.435	.017	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IGKV2OR22-4–HNSC (DFS)

Open the HNSC breakdown →