IGKV2OR2-10

Across TCGA pan-cancer cohorts, IGKV2OR2-10 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated IGKV2OR2-10 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR2-10 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2OR2-10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, OV, and PAAD are the cancer types where IGKV2OR2-10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.627	0.333	.010	81	view →
OV	OS	Tertile	IV	0.397	0.769	.012	18	view →
PAAD	OS	Tertile	II,III,IV	0.743	0.486	.009	18	view →
THCA	OS	Tertile	IV	0.626	1.000	.002	18	view →
LAML	DFS	Tertile	All	0.164	0.499	.006	18	view →
COAD	DFS	Tertile	All	0.175	0.514	.030	9	view →
LIHC	OS	Tertile	III,IV	0.117	0.535	.020	9	view →
CESC	OS	Tertile	II,III,IV	0.944	0.719	.038	6	view →
UCEC	OS	Tertile	All	0.804	0.930	.030	6	view →
SKCM	DFS	Quartile	IV	0.016	0.546	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

IGKV2OR2-10–HNSC (OS)

Open the HNSC breakdown →