IGKV2OR2-10

Across TCGA pan-cancer cohorts, IGKV2OR2-10 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV2OR2-10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2OR2-10 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2OR2-10 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and STAD are the cancer types where IGKV2OR2-10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2OR2-10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.350	<.001	8	view →
BRCA	All	II,III,IV	−0.046	.018	6	view →
STAD	Male	All	−0.294	.020	2	view →
LUAD	All	All	+0.064	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGKV2OR2-10–COAD

Open the COAD breakdown →