IGKV2D-30

Across TCGA pan-cancer cohorts, IGKV2D-30 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV2D-30 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IGKV2D-30 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-30 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC and LUAD are the cancer types where IGKV2D-30 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.984	0.268	.024	7	view →
LUAD	DFS	Tertile	All	0.811	0.256	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV2D-30–PDAC (OS)

Open the PDAC breakdown →