IGKV2D-29

Across TCGA patient cohorts, IGKV2D-29 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV2D-29-associated genes across cancer lineages are CD8+ T-cells, GMP, and Adipocytes. Each is linked with IGKV2D-29 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-29-to-partner and partner-to-IGKV2D-29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by IGKV2D-29-low versus IGKV2D-29-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-29→partner) and Y-score (partner→IGKV2D-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	CD8+ T-cells →	+0.016	+5.453	<.001	.044	3	1
LUSC	GMP →	+0.068	+2.849	<.001	.020	3	1
UCEC	Adipocytes →	+0.032	+3.244	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by IGKV2D-29 expression — PRAD

Explore this box plot interactively →