IGKV2D-28

Across TCGA patient cohorts, IGKV2D-28 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,810 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2D-28-associated GO terms across cancer lineages are B cell mediated immunity, Antimicrobial humoral response, and Antibacterial humoral response. Each is linked with IGKV2D-28 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGKV2D-28-to-partner and partner-to-IGKV2D-28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV2D-28-low versus IGKV2D-28-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-28→partner) and Y-score (partner→IGKV2D-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	B cell mediated immunity →	+0.105	+1.915	<.001	<.001	3	28
THCA	Antimicrobial humoral response →	+0.118	+1.193	<.001	<.001	3	27
THCA	Antibacterial humoral response →	+0.182	+1.207	<.001	<.001	3	27
ESCA	Neutrophil migration →	+0.068	+1.460	<.001	<.001	3	26
THCA	Complement activation →	+0.155	+1.124	<.001	<.001	3	26
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.164	+1.113	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,810 associations by consensus.

B cell mediated immunity by IGKV2D-28 expression — ESCA

Explore this box plot interactively →