IGKV2D-28

Across TCGA pan-cancer cohorts, IGKV2D-28 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV2D-28 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-28 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-28 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where IGKV2D-28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.483	0.295	<.001	143	view →
SKCM	DFS	Median	All	0.684	0.566	<.001	114	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	63	view →
CESC	OS	Quartile	All	0.920	0.765	.006	32	view →
UCS	OS	Tertile	II,III,IV	0.807	0.397	.018	30	view →
THYM	DFS	Median	III,IV	0.402	0.907	.004	25	view →
KIRP	OS	Tertile	All	0.416	0.776	.005	24	view →
DLBC	OS	Tertile	All	0.267	0.932	.005	19	view →
CHOL	DFS	Tertile	All	0.770	0.355	.045	15	view →
LUSC	DFS	Median	III,IV	0.444	0.182	.003	11	view →
STAD	DFS	Median	All	0.564	0.685	.017	10	view →
BLCA	OS	Tertile	III,IV	0.394	0.183	.021	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV2D-28–HNSC (OS)

Open the HNSC breakdown →