IGKV2D-28

Across TCGA patient cohorts, IGKV2D-28 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV2D-28-associated genes across cancer lineages are RN7SL705P, RN7SL462P, and RN7SL483P. Each is linked with IGKV2D-28 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-28-to-partner and partner-to-IGKV2D-28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL705P grouped by IGKV2D-28-low versus IGKV2D-28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-28→partner) and Y-score (partner→IGKV2D-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL705P →	+0.321	+5.358	<.001	.006	3	2
SKCM	RN7SL462P →	+0.109	+7.816	<.001	.008	3	1
LUSC	RN7SL483P →	+0.197	+5.273	<.001	.006	3	1
LUSC	LINC02131 →	+0.207	+4.984	<.001	.009	3	1
LUSC	MIR4686 →	+0.631	+5.093	<.001	.008	3	1
LUSC	RN7SL366P →	+0.169	+5.038	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

RN7SL705P by IGKV2D-28 expression — UCEC

Explore this box plot interactively →