IGKV2D-24

Across TCGA patient cohorts, IGKV2D-24 mutation is significantly associated with the RNA expression of many other genes, with 152 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV2D-24-associated genes across cancer lineages are RN7SL346P, BNIP3P41, and RNA5SP174. Each is linked with IGKV2D-24 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-24-to-partner and partner-to-IGKV2D-24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL346P grouped by IGKV2D-24-low versus IGKV2D-24-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-24→partner) and Y-score (partner→IGKV2D-24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL346P →	+0.178	+4.716	.001	.003	3	2
BLCA	BNIP3P41 →	+0.063	+8.051	<.001	<.001	3	2
LUSC	RNA5SP174 →	+1.693	+3.618	<.001	.004	3	2
LUSC	LINC02497 →	+0.282	+2.852	<.001	.004	3	2
LIHC	MAGEB4 →	+0.072	+5.758	<.001	.003	3	1
LIHC	KRT74 →	+0.181	+5.355	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 152 associations by consensus.

RN7SL346P by IGKV2D-24 expression — HNSC

Explore this box plot interactively →