IGKV2D-24

Across TCGA pan-cancer cohorts, IGKV2D-24 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV2D-24 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-24 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-24 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and UVM are the cancer types where IGKV2D-24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.806	0.695	<.001	141	view →
BRCA	DFS	Tertile	All	0.972	0.911	<.001	80	view →
UVM	OS	Tertile	III,IV	0.070	0.843	<.001	63	view →
UCEC	OS	Tertile	III,IV	0.743	0.446	.001	62	view →
SKCM	DFS	Tertile	All	0.874	0.684	<.001	59	view →
COAD	DFS	Median	All	0.609	0.443	<.001	45	view →
GBM	OS	Tertile	All	0.201	0.463	.001	36	view →
KIRP	OS	Quartile	All	0.555	0.807	.001	30	view →
LGG	DFS	Tertile	All	0.219	0.471	.004	24	view →
SARC	DFS	Tertile	All	0.625	0.461	.004	19	view →
READ	DFS	Tertile	IV	0.838	0.390	.003	18	view →
LUSC	OS	Quartile	II,III,IV	0.496	0.874	.014	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV2D-24–HNSC (OS)

Open the HNSC breakdown →