IGKV2D-18

Across TCGA pan-cancer cohorts, IGKV2D-18 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGKV2D-18 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2D-18 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2D-18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and GBM are the cancer types where IGKV2D-18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.790	0.662	<.001	140	view →
SKCM	DFS	Tertile	All	0.736	0.579	<.001	123	view →
GBM	OS	Tertile	All	0.044	0.416	<.001	54	view →
UCEC	DFS	Tertile	All	0.323	0.687	.013	30	view →
UCS	OS	Tertile	II,III,IV	1.000	0.418	.016	24	view →
OV	OS	Tertile	All	0.526	0.298	.007	18	view →
KIRP	DFS	Tertile	All	0.507	0.820	.006	12	view →
ESCA	OS	Tertile	III,IV	0.630	0.346	.029	11	view →
DLBC	OS	Tertile	IV	0.147	1.000	.045	9	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	9	view →
STAD	OS	Median	IV	0.563	0.193	.016	9	view →
TGCT	OS	Tertile	All	0.865	0.990	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGKV2D-18–HNSC (DFS)

Open the HNSC breakdown →