IGKV2D-18

Across TCGA pan-cancer cohorts, IGKV2D-18 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGKV2D-18’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2D-18 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2D-18 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and LUAD are the cancer types where IGKV2D-18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2D-18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.697	<.001	11	view →
READ	All	All	−0.621	<.001	7	view →
LUAD	All	All	+0.397	<.001	7	view →
BRCA	Female	All	−0.184	.020	4	view →
STAD	Male	All	−0.594	.021	3	view →
THCA	Male	III,IV	+0.155	.040	2	view →
KIRC	Male	All	+0.088	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGKV2D-18–COAD

Open the COAD breakdown →