IGKV2-36

Across TCGA patient cohorts, IGKV2-36 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,794 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2-36-associated GO terms across cancer lineages are CD4-positive, alpha-beta T cell activation, Regulation of leukocyte apoptotic process, and Negative regulation of leukocyte apoptotic process. Each is linked with IGKV2-36 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGKV2-36-to-partner and partner-to-IGKV2-36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4-positive, alpha-beta T cell activation grouped by IGKV2-36-low versus IGKV2-36-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-36→partner) and Y-score (partner→IGKV2-36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CD4-positive, alpha-beta T cell activation →	+0.068	+0.028	<.001	.005	3	7
STAD	Regulation of leukocyte apoptotic process →	+0.090	+0.032	<.001	.001	3	6
STAD	Negative regulation of leukocyte apoptotic process →	+0.090	+0.032	<.001	.001	3	6
STAD	Positive regulation of leukocyte apoptotic process →	+0.072	+0.029	<.001	.003	3	6
STAD	Regulation of CD4-positive, alpha-beta T cell activation →	+0.068	+0.030	<.001	.003	3	6
STAD	Positive regulation of leukocyte cell-cell adhesion →	+0.082	+0.042	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,794 associations by consensus.

CD4-positive, alpha-beta T cell activation by IGKV2-36 expression — STAD

Explore this box plot interactively →