IGKV2-36

Across TCGA pan-cancer cohorts, IGKV2-36 RNA is linked to patient survival in 5 of 34 cancer types, making it the most broadly survival-associated IGKV2-36 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGKV2-36 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2-36 expression acts as an unfavorable survival marker.

ESCA, READ, and DLBC are the cancer types where IGKV2-36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Tertile	II,III,IV	0.227	0.712	<.001	108	view →
READ	OS	Tertile	III,IV	0.287	0.772	.030	39	view →
DLBC	OS	Tertile	All	0.383	0.782	.005	36	view →
LUAD	DFS	Tertile	II,III,IV	0.129	0.655	<.001	18	view →
LGG	OS	Tertile	All	0.350	0.811	.019	18	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV2-36–ESCA (OS)

Open the ESCA breakdown →