IGKV2-30

Across TCGA patient cohorts, IGKV2-30 protein abundance is significantly associated with the RNA expression of many other genes, with 1,311 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2-30-associated genes across cancer lineages are PPM1F, MFNG, and GRK3. Each is linked with IGKV2-30 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-30-to-partner and partner-to-IGKV2-30 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2-30 versus PPM1F in BRCA, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-30→partner) and Y-score (partner→IGKV2-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPM1F →	+0.448	+1.027	<.001	.002	3	1
BRCA	MFNG →	+0.566	+1.170	.003	.001	3	1
BRCA	GRK3 →	+0.746	+0.981	<.001	.002	3	1
BRCA	PIK3IP1 →	+0.609	+1.230	.002	.002	3	1
BRCA	CYB5R3 →	+0.412	+1.014	.001	.003	3	1
BRCA	CSF2RB →	+0.901	+1.144	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,311 associations by consensus.

IGKV2-30 vs PPM1F — BRCA

Explore this scatter interactively →