IGKV2-28

Across TCGA pan-cancer cohorts, IGKV2-28 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV2-28 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher IGKV2-28 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2-28 expression acts as an unfavorable survival marker.

OV and LIHC are the cancer types where IGKV2-28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.289	0.692	.020	18	view →
LIHC	OS	Median	All	0.177	0.783	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV2-28–OV (OS)

Open the OV breakdown →