IGKV2-26

Across TCGA pan-cancer cohorts, IGKV2-26 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGKV2-26 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher IGKV2-26 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2-26 expression acts as an unfavorable survival marker.

LGG and HNSC are the cancer types where IGKV2-26 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.132	0.830	<.001	12	view →
HNSC	OS	Median	All	0.232	0.686	.027	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

IGKV2-26–LGG (OS)

Open the LGG breakdown →