IGKV2-19

Across TCGA patient cohorts, IGKV2-19 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,070 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV2-19-associated GO terms across cancer lineages are Positive regulation of inflammatory response, Regulation of CD4-positive, alpha-beta T cell activation, and Cellular response to biotic stimulus. Each is linked with IGKV2-19 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV2-19-to-partner and partner-to-IGKV2-19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of inflammatory response grouped by IGKV2-19-low versus IGKV2-19-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-19→partner) and Y-score (partner→IGKV2-19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of inflammatory response →	+0.076	+0.162	<.001	<.001	3	8
STAD	Regulation of CD4-positive, alpha-beta T cell activation →	+0.078	+0.136	<.001	<.001	3	6
STAD	Cellular response to biotic stimulus →	+0.088	+0.151	<.001	<.001	3	6
LUSC	Immunoglobulin production →	+0.091	+0.026	<.001	<.001	3	6
STAD	Regulation of endocytosis →	+0.087	+0.151	<.001	<.001	3	6
STAD	Negative regulation of Rho protein signal transduction →	+0.087	+0.135	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,070 associations by consensus.

Positive regulation of inflammatory response by IGKV2-19 expression — STAD

Explore this box plot interactively →