IGKV2-19

Across TCGA pan-cancer cohorts, IGKV2-19 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGKV2-19 data layer.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher IGKV2-19 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2-19 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

READ, BRCA, and KIRP are the cancer types where IGKV2-19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	II,III,IV	0.083	0.919	<.001	72	view →
BRCA	OS	Tertile	III,IV	0.616	0.906	<.001	66	view →
KIRP	OS	Tertile	All	0.185	0.709	<.001	57	view →
KIRC	DFS	Tertile	All	0.406	0.649	.002	30	view →
OV	DFS	Tertile	All	0.318	0.543	.031	30	view →
STAD	DFS	Tertile	IV	0.087	0.415	<.001	27	view →
LUAD	DFS	Tertile	All	0.855	0.334	.011	24	view →
UCS	DFS	Tertile	All	0.136	0.523	.034	18	view →
LIHC	DFS	Tertile	All	0.097	0.543	.033	18	view →
BLCA	DFS	Tertile	III,IV	0.138	0.499	.001	15	view →
SKCM	OS	Tertile	All	0.329	0.780	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGKV2-19–READ (OS)

Open the READ breakdown →