IGKV2-19

Across TCGA patient cohorts, IGKV2-19 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV2-19-associated genes across cancer lineages are MIR5705. Each is linked with IGKV2-19 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-19-to-partner and partner-to-IGKV2-19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5705 grouped by IGKV2-19-low versus IGKV2-19-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-19→partner) and Y-score (partner→IGKV2-19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5705 →	+0.436	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

MIR5705 by IGKV2-19 expression — LUSC

Explore this box plot interactively →