IGKV2-18

Across TCGA patient cohorts, IGKV2-18 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,654 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV2-18-associated GO terms across cancer lineages are B cell receptor signaling pathway, Antimicrobial humoral response, and Antibacterial humoral response. Each is linked with IGKV2-18 in more than 27 cancer types. Because this analysis shows association rather than direction, both IGKV2-18-to-partner and partner-to-IGKV2-18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGKV2-18-low versus IGKV2-18-high in SKCM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-18→partner) and Y-score (partner→IGKV2-18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	B cell receptor signaling pathway →	+0.079	+0.476	<.001	<.001	3	28
SARC	Antimicrobial humoral response →	+0.114	+0.155	<.001	<.001	3	27
THCA	Antibacterial humoral response →	+0.170	+0.600	<.001	<.001	3	27
THCA	B cell mediated immunity →	+0.100	+0.635	<.001	<.001	3	26
STAD	Immunoglobulin production →	+0.086	+0.613	<.001	<.001	3	26
GBM	Positive regulation of respiratory burst →	+0.143	+0.041	<.001	.006	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,654 associations by consensus.

B cell receptor signaling pathway by IGKV2-18 expression — SKCM

Explore this box plot interactively →