IGKV2-18

Across TCGA pan-cancer cohorts, IGKV2-18 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV2-18 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2-18 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2-18 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, THYM, and LUSC are the cancer types where IGKV2-18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.672	0.540	<.001	145	view →
THYM	OS	Tertile	All	0.851	1.000	.002	39	view →
LUSC	OS	Median	All	0.338	0.607	.003	30	view →
GBM	OS	Tertile	All	0.106	0.428	<.001	27	view →
KIRC	DFS	Tertile	All	0.682	0.837	.003	26	view →
OV	OS	Tertile	III,IV	0.755	0.857	.015	24	view →
CESC	OS	Tertile	IV	0.877	0.389	.016	20	view →
DLBC	OS	Tertile	III,IV	0.172	1.000	.014	18	view →
KIRP	OS	Tertile	All	0.493	0.754	.011	18	view →
CHOL	OS	Tertile	All	0.113	0.623	.040	18	view →
STAD	OS	Median	IV	0.711	0.243	.012	12	view →
SKCM	DFS	Quartile	III,IV	0.653	0.460	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV2-18–HNSC (DFS)

Open the HNSC breakdown →