IGKV2-14

Across TCGA patient cohorts, IGKV2-14 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,388 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV2-14-associated GO terms across cancer lineages are Immunoglobulin production, T cell selection, and Positive regulation of neutrophil migration. Each is linked with IGKV2-14 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGKV2-14-to-partner and partner-to-IGKV2-14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin production grouped by IGKV2-14-low versus IGKV2-14-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-14→partner) and Y-score (partner→IGKV2-14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Immunoglobulin production →	+0.082	+0.045	<.001	<.001	3	9
STAD	T cell selection →	+0.082	+0.053	<.001	<.001	3	9
STAD	Positive regulation of neutrophil migration →	+0.077	+0.049	<.001	<.001	3	9
STAD	B cell receptor signaling pathway →	+0.105	+0.102	<.001	<.001	3	9
STAD	Regulation of B cell activation →	+0.087	+0.052	<.001	<.001	3	9
STAD	Positive regulation of B cell activation →	+0.077	+0.055	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,388 associations by consensus.

Immunoglobulin production by IGKV2-14 expression — THCA

Explore this box plot interactively →