IGKV2-14

Across TCGA pan-cancer cohorts, IGKV2-14 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGKV2-14 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher IGKV2-14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV2-14 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

STAD, MESO, and THCA are the cancer types where IGKV2-14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Tertile	IV	0.045	0.495	<.001	54	view →
MESO	OS	Tertile	II,III,IV	0.195	0.583	<.001	54	view →
THCA	OS	Tertile	III,IV	0.196	0.888	.002	36	view →
KIRC	OS	Tertile	All	0.401	0.633	.011	30	view →
THYM	DFS	Tertile	III,IV	0.205	0.774	.007	18	view →
LUAD	DFS	Tertile	IV	0.320	0.721	.034	18	view →
LGG	DFS	Tertile	All	0.224	0.738	.013	18	view →
HNSC	OS	Tertile	IV	0.001	0.643	<.001	18	view →
SKCM	DFS	Tertile	All	0.612	0.197	.027	12	view →
SARC	OS	Tertile	All	0.482	0.865	.003	12	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
UCEC	DFS	Tertile	All	0.805	0.899	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGKV2-14–STAD (DFS)

Open the STAD breakdown →