IGKV2-10

Across TCGA pan-cancer cohorts, IGKV2-10 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGKV2-10 data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher IGKV2-10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2-10 expression acts as an unfavorable survival marker, although some lineages such as CESC and ESCA show a favorable association.

CHOL, DLBC, and LUAD are the cancer types where IGKV2-10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.164	0.741	<.001	72	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
CESC	DFS	Tertile	III,IV	1.000	0.565	.032	18	view →
ESCA	DFS	Tertile	All	0.835	0.475	.032	9	view →
STAD	OS	Tertile	IV	0.682	0.258	.040	6	view →
KIRC	DFS	Tertile	II,III,IV	1.000	0.456	.034	6	view →
SKCM	OS	Tertile	III,IV	0.651	0.810	.018	6	view →
THCA	DFS	Tertile	III,IV	0.684	0.931	.029	6	view →
HNSC	OS	Tertile	IV	0.405	0.648	.040	6	view →
LUSC	OS	Quartile	II,III,IV	0.263	0.599	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGKV2-10–CHOL (OS)

Open the CHOL breakdown →