IGKV2-10

Across TCGA pan-cancer cohorts, IGKV2-10 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGKV2-10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2-10 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2-10 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV2-10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.237	.012	3	view →
LUAD	All	II,III,IV	+0.074	.034	2	view →
BRCA	Female	II,III,IV	−0.051	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IGKV2-10–COAD

Open the COAD breakdown →