IGKV1OR22-5

Across TCGA patient cohorts, IGKV1OR22-5 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,964 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1OR22-5-associated GO terms across cancer lineages are Humoral immune response mediated by circulating immunoglobulin, Antigen receptor-mediated signaling pathway, and B cell receptor signaling pathway. Each is linked with IGKV1OR22-5 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGKV1OR22-5-to-partner and partner-to-IGKV1OR22-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Humoral immune response mediated by circulating immunoglobulin grouped by IGKV1OR22-5-low versus IGKV1OR22-5-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR22-5→partner) and Y-score (partner→IGKV1OR22-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.163	+1.151	<.001	<.001	3	29
TGCT	Antigen receptor-mediated signaling pathway →	+0.061	+0.982	<.001	<.001	3	28
ESCA	B cell receptor signaling pathway →	+0.083	+0.672	<.001	<.001	3	28
THCA	Complement activation →	+0.153	+1.146	<.001	<.001	3	28
THCA	Complement activation, classical pathway →	+0.197	+1.175	<.001	<.001	3	28
ESCA	B cell mediated immunity →	+0.107	+0.973	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,964 associations by consensus.

Humoral immune response mediated by circulating immunoglobulin by IGKV1OR22-5 expression — THCA

Explore this box plot interactively →