IGKV1OR2-9

Across TCGA pan-cancer cohorts, IGKV1OR2-9 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-9 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-9 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1OR2-9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, UVM, and CESC are the cancer types where IGKV1OR2-9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.676	0.546	<.001	144	view →
UVM	OS	Tertile	II,III,IV	0.189	0.728	.002	72	view →
CESC	OS	Median	All	0.873	0.741	.003	52	view →
LIHC	DFS	Tertile	All	0.728	0.515	.004	45	view →
CHOL	DFS	Tertile	All	0.782	0.299	.016	27	view →
SKCM	DFS	Quartile	III,IV	0.673	0.452	.002	26	view →
PAAD	OS	Median	II,III,IV	0.653	0.454	.007	21	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
LUAD	DFS	Tertile	II,III,IV	0.726	0.466	.008	17	view →
BRCA	OS	Tertile	All	0.614	0.561	.012	16	view →
COAD	DFS	Tertile	IV	0.865	0.335	.011	13	view →
KIRP	DFS	Tertile	II,III,IV	0.369	0.718	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

IGKV1OR2-9–HNSC (DFS)

Open the HNSC breakdown →